Cloves Syndrome: Severe Neonatal Presentation
Published: April 1, 2017 | DOI: https://doi.org/10.7860/JCDR/2017/23801.9719
Silvana Acosta, Viviana Torres, María Paulos, Ignacio Cifuentes
1. Assistant Professor, Department of Plastic Surgery Section, Surgery Division, Medical School,
Pontificia Universidad Católica de Chile, Santiago, Santiago, Chile.
2. Surgeon, Department of Pediatric Surgery, Hospital Félix Bulnes, Santiago, Santiago, Chile.
3. Surgeon, Department of Plastic Surgery Unit, Hospital de Niños Roberto del Río, Santiago, Santiago, Chile.
4. Resident, Department of Plastic Surgery Section, Surgery Division, Medical School,
Pontificia Universidad Católica de Chile, Santiago, Santiago, Chile.
Correspondence
Dr. Silvana Acosta,
Cardenal Newman 821, Las Condes, Santiago, Chile.
E-mail: acosta.doctora@gmail.com
Congenital Lipomatous Overgrowth, Vascular Malformations, Epidermal Nevi and Spinal Abnormalities (CLOVES syndrome) is a newly described and rare overgrowth disorder with serious morbidity. The course of this disease is not well understood and few cases have been reported among neonates. Moreover, not all of the signs of this syndrome are present at birth, making a high index of suspicion necessary. We present a cohort of three newborns with CLOVES syndrome who died due to septic and hemodynamic complications directly related to extensive vascular malformations. We discuss the clinical presentation in the neonatal period and propose a clinical classification.
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